eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2022-03-31 15 1 261 267 10.13005/bpj/2362 43482 article Abdulaziz K. Al Mouslem 1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al Ahsa 31982, Saudi Arabia. Objectives: To investigate the hypoglycemic and hypolipidemic potentials of Picris babylonica extract in streptozotocin (STZ) induced diabetes in rats. Methods: Animals were injected with 40mg/kg of STZ to induce diabetes, a common diabetic model. Development of the disease were assessed by measuring blood glucose level 3 days prior systemic administration of STZ and following STZ injection. Animals received 200mg/kg and 400mg/kg of Picris babylonica extract and 0.6mg/kg of glibenclamide, standard, by oral rout for 14 consecutive days.  Results: Administration of the Picris babylonica extract significantly decreased serum blood glucose, total cholesterol, triglycerides, and low-density lipoprotein-cholesterol. In addition, high density lipoprotein-cholesterol level significantly enhanced as compared to standard. Conclusion: Picris babylonica extract demonstrated beneficial effects in lowering blood glucose and improving lipid profile, therefore, Picris babylonica extract could be developed as hypoglycemic and hypolipidemic therapy. https://biomedpharmajournal.org/vol15no1/antidiabetic-and-hypolipidemic-potentials-of-extract-of-picris-babylonica-in-streptozotocin-induced-diabetic-model-in-rats/ Asteraceae  DPPH  Hypolipidemic  Streptozotocin Antidiabetic  Picris babylonica