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<records>

  <record>
    <language>eng</language>
          <publisher>Oriental Scientific Publishing Company</publisher>
        <journalTitle>Biomedical and Pharmacology Journal</journalTitle>
          <issn>0974-6242</issn>
            <publicationDate>2021-12-30</publicationDate>
    
        <volume>14</volume>
        <issue>4</issue>

 
    <startPage>1823</startPage>
    <endPage>1829</endPage>

	 
      <doi>10.13005/bpj/2281</doi>
        <publisherRecordId>41303</publisherRecordId>
    <documentType>article</documentType>
    <title language="eng">Solubility of Nifedipine by Shake Flask UV-Spectrometry; Review of Safety Concerns in Pregnancy</title>

    <authors>
	 


      <author>
       <name>Soham Samajpaty</name>

 
		
	<affiliationId>1</affiliationId>
      </author>
    

	

	

	


	


	
    </authors>
    
	    <affiliationsList>
	    
		
		<affiliationName affiliationId="1">Department of General Medicine, International Faculty, Russian National Research Medical University named after NI Pirogov, Moscow, Russian Federation</affiliationName>
    

		
		
		
		
		
	  </affiliationsList>






    <abstract language="eng">Nifedipine is chemically dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, a dihydropyridine derivative used frequently as anti-hypertensive. It is a L- type calcium channel blocker (CCB). Few analogical discrepancies were found between Nifedipine’s clinical output report and chemical analysis of solubility. The ambition of this research is to conduct a re-check and proper quantification of partition co-efficient (logP) of Nifedipine and clarify the discrepancy and rectify if any mistake has been done in recent past. The method used is the “gold standard” <em>shake-flask method</em> followed by analysis through UV-scpectrophotmetry.</abstract>

    <fullTextUrl format="html">https://biomedpharmajournal.org/vol14no4/solubility-of-nifedipine-by-shake-flask-uv-spectrometry-review-of-safety-concerns-in-pregnancy/</fullTextUrl>

<keywords language="eng">

      
        <keyword>logP of Nifedipine</keyword>
      

      
        <keyword> Medicine</keyword>
      

      
        <keyword> Nifedipine</keyword>
      

      
        <keyword> Pharmacology</keyword>
      

      
        <keyword> Solubility Of Nifedipine</keyword>
      
</keywords>
  </record>
</records>