eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2021-09-30 14 3 1501 1507 10.13005/bpj/2251 40529 article Giorgio Attina 1 Stefano Mastrangelo 1 Antonio Ruggiero 1 Pediatric Oncology Unit, Fondazione Policlinico Universitario A.Gemelli IRCCS, Universita’ Cattolica Sacro Cuore, Rome, Italy. Bisphosphonates have found in recent years an increasingly wide application in adult neoplastic diseases and osteoporosis. Their mechanism of action is based on the inhibition of bone turnover favouring, in particular, the mineralization and the reduction of the frequency of the remodelling cycles. The fields of application of bisphosphonates in paediatric age are constantly evolving although new trials are needed to define the schedule of administration and their long-term side effects. https://biomedpharmajournal.org/vol14no3/the-role-of-bisphosphonates-in-childhood-diseases/ Bisphosphonates  Bone  Children