eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2021-09-30 13 4 1175 1187 10.13005/bpj/2220 40872 article Pacôme Kouadio N’Go 1 Lazare Tehoua1 1 Omar Touhami Ahmed Ahami 2 Fatima-Zahra Azzaoui 2 Youssef Aboussaleh 2 Peleforo Gon COULIBALY University,Training and Research Unit of Biological Sciences, P.O.Box 1328, Korhogo, Ivory Coast Clinical and Cognitive Neurosciences Group, Biology and Health Lab, Ibn Tofail University, P.O.Box 133, Kenitra, Morocco Chrysophyllum perpulchrum is an endemic medicinal plant used in ivorian tranditional pharmacopeiaeas antipyretic to heal malaria fever. Since three flavonoid compounds have been isolated, catechin and two procyanid in dimers, we are proposed to testthe neuroprotective effectiveness effects using a rat model of Alzheimer Disease (AD). Adult Wistar rats were used as model.Sham-operated rats as controlwere injected by intracerebroventricular route (i.c.v) with1% ammonia(Group1), Aβ rats were microinjected with 10µg/side (i.c.v route, (Group 2)).From 14^th day post-surgery required for neuro inflammation and oxidative stress induction,some Aβ-injected rats were daily treated with the extract (300 mg/kg bw, oral route, (Group 3)) for 21 days,sham-operated rats were treated only with plant extract (300 mg/kg bw, oral route, (Group 4)). Rats were then submitted to memory tests with Y maze, object recognition test and Morris water maze. Some oxidative stress markershave been assessed.AD-like rats exhibited significant recognition memory as well as learning and spatial memory deficits.The treatment of AD like-rats with methanolic extract of Chrysophyllum perpulchrum alleviated cognitive disorders by improving the memory recognition index and spatial learning strategy to find the hidden platform. Furthermore,Chrysophyllum perpulchrum extract prevented significantly Aβ-induced lipid proxidation through a decrease of malondialdehyde (MDA) level in the hippocampus and the prefrontal cortex, and also helped to increase the non protein-thiol (NP-SH) antioxidant level.These findings suggest the neuroprotective actions of Chrysophyllum perpulchrum extract on AD-like rats. However,further pharmacological studies are needed to test ability of isolated compounds from Chrysophyllum perpulchrum to counteract full Aβ physiopathology mechanisms before promising to be a drug candidate for AD treatment. https://biomedpharmajournal.org/vol14no3/cognitive-disorders-and-oxidative-stress-status-attenuated-by-chrysophyllum-perpulchrum-extract-in-alzheimer-like-rat-model-of-intracerebroventricular-a%ce%b21-40-injection/ Alzheimer disease brain  Chrysophyllum perpulchrum  oxidative stress recognition memory spatial learning