eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2021-06-30 14 2 755 760 10.13005/bpj/2179 38657 article Rakhi T 1 Ranjan R K 1 Sonal Bhat 1 Sunil B V 1 Department of Anaesthesiology Kasturba Medical College, Mangaluru Manipal academy of higher education, Mangaluru Karnataka, India Background: To compare the efficacy of saline, lignocaine 2% and Lignocaine 4% in the endotracheal tube cuff to decrease the incidence of post operative cough and sore throat. A unique, efficient and easy method designed to decrease cough and sore throat during emergence. Hence there was a need for the study. Methods: After approval from institutional Ethical Committee, Kasturba Medical college, Mangaluru and written informed consent from 120 patients of A.S.A class I & II, aged between 18-60 years posted for various surgeries were included.  Randomization was done into three groups of 40 patients each. Group 1 – Normal saline, group 2 - 2% Lignocaine and group 3 - 4% Lignocaine. Postoperatively patients were assessed for incidence of cough and sore throat pain based on visual analogue scale (VAS) Results: 65% of patients in group 2 and 72% of patients in group 3 were extubated smoothly, whereas only 20% of patients in group 1 had smooth extubation, p<0.001. There was significant difference in sore throat pain and cough in group 2 and 3 when compared to group 1. Conclusion: The incidence of sore throat and cough was significantly reduced with Lignocaine in the endotracheal tube cuff when compared to saline. Lignocaine 4% was found to be far more better than 2% in reducing sore throat. https://biomedpharmajournal.org/vol14no2/comparison-between-the-efficacy-of-saline-alkalinised-lignocaine-2-and-alkalinised-lignocaine-4-in-the-cuff-of-endotracheal-tube-to-reduce-the-incidence-of-cough-and-sorethroat-during-extubation/ Alkalinised Lignocaine 2% 4%  Cough Emergence  Saline  Sore Throat