eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2021-06-30 14 2 607 621 10.13005/bpj/2163 39227 article Olagoke Zacchaeus Olatunde 1 Danian Tian 4 Jianping Yong 2 Canzhong Lu 3 Fujian Institute of Research on the Structure of Matter, Haixi Institute, Chinese Academy of Sciences, Fujian, China Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, China University of Chinese Academy of Sciences, Beijing, China Ningxia Medical University, Ningxia, China The essential oil was obtained from the seeds of Garcina kola and its compositions were investigated by GC-MS and ICP-MS, respectively. 74 organic compounds and 9 trace elements beneficial to human health were confirmed in this oil. Then, the in vitro antioxidant and anticancer activities were evaluated accordingly. The results showed that this essential oil exhibited stronger antioxidant activity against DPPH⸱ with the scavenging rate of 94.19% at 0.2 mg/mL, as well as potent inhibition against gastric cancer, lung cancer(A549) and Hela cell lines with the inhibitions of 96.397%±0.929, 98.005%±0.513 and 94.77±2.09 respectively at 8.3 mg/mL. While it exhibited moderate inhibition against the human breast carcinoma cells (MCF-7) with the inhibition of 59.257%±4.544 at 8.3mg/mL. In consideration of Garcina kola being consumed in Nigeria for a long time, this essential oil obtained from the Garcina kola can be used in the field of food, cosmetic or drugs. https://biomedpharmajournal.org/vol14no2/chemical-compositions-of-the-essential-oil-extracted-from-the-seeds-of-garcina-kola-and-its-biological-activities/ Anticancer Activities  Antioxidant  Chemical Compositions  Essential Oil  Garcina Kola