eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2021-03-30 14 1 1 5 10.13005/bpj/2094 37978 article Chloroquine-induced Prolonged QT Interval in COVID-19 Patients in Indonesia: Case Series Putu Dyah Widyaningsih 1 Putu Gita Pranata Putra 1 DG Wedha Asmara 2 Erna Bagiari 2 Agus Santosa 3 Harapan Harapan 4 1Department of Internal Medicine, Faculty of Medicine and Health Sciences Universitas Warmadewa, Denpasar, Bali 80235, Indonesia 2Department of Internal Medicine, Sanjiwani Hospital, Denpasar, Bali 80235, Indonesia 3Department of Pharmacology, Faculty of Medicine and Health Sciences Universitas Warmadewa, Denpasar, Bali 80235, Indonesia 4Department of Microbiology, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh 23111, Indonesia 5Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh 23111, Indonesia 6Tropical Disease Centre, School of Medicine, Syiah Kuala University, Banda Aceh, Aceh 23111, Indonesia

The treatment of corona virus disease 2019 (COVID-19)remains in debate, and the use of chloroquine has not been validated by accurate clinical trials.The aim of this study was to provide the possible cardiotoxicity effect of chloroquine in patients with COVID-19. This study was a case-series of prolonged QT interval of COVID-19 patients treated with chloroquine in a hospital in Bali, Indonesia. There were two cases of COVID-19 with exhibited a prolonged QT interval after being administrated of chloroquine. The prolonged QT interval returned to normal after chloroquine was stopped.These cases alert us the cardiotoxicity effect of chloroquine and the need for serial electro-cardiography monitoring before and during therapy. In conclusion, although antiviral and anti-inflammation properties of chloroquine on COVID-19 are promising, its cardiotoxicity effects should be monitored closely for less harm to the patients.

 https://biomedpharmajournal.org/vol14no1/chloroquine-induced-prolonged-qt-interval-in-covid-19-patients-in-indonesia-case-series/ Chloroquine  Cardiotoxicity  COVID-19  long QT syndrome  LQTS