eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-12-30 13 4 2081 2085 10.13005/bpj/2088 36417 article Rizaldy Taslim Pinzon 1 Vanessa Veronica 1 Yohana Ratih Tirtaningtyas Dian Christi 1 Regina Ayudyaningsari Pradani 2 Department of Neurology, Faculty of Medicine, Duta Wacana Christian University, Dr. Wahidin Sudirohusodo st. 5-25, Yogyakarta 55224, Indonesia Department of Pharmacy, Sanata Dharma University, Paingan st., Yogyakarta 55281, Indonesia Background: Chronic kidney failure will lead to decline in immune system. Vitamin B considered has essential roles in immune system, including lymphocyte count. Aims: Measure the effects of vitamin B combination injection on lymphocyte count in chronic kidney failure patients. Methods: This was quasi-experimental study with one group pretest-posttest design from the period of August 2018 - October 2018 at Bethesda Hospital and Panti Rapih Hospital, Yogyakarta, Indonesia. Subjects received vitamin B combination injection (intravenous) after each hemodialysis. Lymphocyte count were measured 3 times namely visit I (before first hemodialysis), visit II (after second hemodialysis), and visit III (after third hemodialysis). Results: The data were obtained from 115 chronic kidney failure patients, consist of 75 male and 40 female. The most common age group in this study was 40-59 years old. There were no significant improvements of lymphocyte counts, both on visit II compared to visit I (1285.713±475.9829/mm³ vs 1504.219±1148.974/mm³; p: 0.065) as well as visit III compared to visit I (1285.713±475.9829/mm³ vs 1315.192±658.6673/mm³; p: 0.766). Conclusion: Vitamin B combination injection has no significant effects on lymphocyte count in chronic kidney failure patients. Intravenous vitamin B was safe for chronic kidney failure patients. https://biomedpharmajournal.org/vol13no4/the-effects-of-vitamin-b-combination-injection-on-lymphocyte-count-in-chronic-kidney-failure-patients/ Chronic Kidney Failure  Hemodialysis  Immune  Lymphocyte  Vitamin B