eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-12-30 13 4 1781 1790 10.13005/bpj/2053 36403 article Nicolas Padilla-Raygoza 1 Cuauhtémoc Sandoval Salazar 2 Xóchitl Sofía Ramírez-Gómez 3 Efraín Navarro-Olivos 4 María de Jesus Gallardo-Luna 4 Francisco J. Magos-Vazquez 4 Departmentl of Medicine, University of Celaya, Celaya México 2Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya-Salvatierra, University of Guanajuato, Celaya, Mexico 3Department of Clinical Nursing, Division of Health Sciences and Engineering, Campus Celaya-Salvatierra, University of Guanajuato, Celaya, Mexico 4Institute of Public Health from Guanajuato State, Guanajuato, Mexico Introduction.Mexico has high number of new cases of Coronavirus Infectious Disease-19 and high rates of diabetes, hypertension, obesity, smoking, that can increase the mortality. The aim was to analyze the evolution of  the disease until June 30^th, 2020; to know the Cause-SpecificMortality Rate by each state from Mexico and the effect of co-morbidities on mortality for Coronavirus Infectious Disease-19. Methods. An ecological study was designed with public data of National Epidemiological Surveillance System to compare the hospital infrastructure (beds) and Cause-Specific Mortality Rate in each state from Mexico and  analyze the effect of co-morbidities in mortality by Coronavirus Infectious Disease.19. It was used t-Student test, Z for two proportions, P-values, and OR, CI95%, and logistic regression .Results. From 509,539 registries, 226,089 (44.37%) were confirmed cases and 27,769 deaths were reported (12.28%). The states with higher mortality were Morelos, Baja California, Chihuahua, Guerrero. There was a lineal relationship between number of beds and cause-specific mortality rate (P<,05). Diabetes, chronic obstructive pulmonary disease, immunosuppression, hypertension, cardiovascular disease, chronic kidney disease and obesity shown a stronger effect on mortality by coronavirus disease (OR higher than 2). Asthma shown a protective effect on mortality from coronavirus disease in Mexican population. Conclusion.The spread on coronavirus disease is active in Mexico. The comorbidities had a stronger effect on mortality of Coronavirus disease. https://biomedpharmajournal.org/vol13no4/status-of-novel-coronavirus-disease-and-analysis-of-mortality-in-mexico-until-june-30th-2020-an-ecological-study/ COVID-19  Diabetes  Hypertension  Mortality  Obesity  Smoking  SARS-CoV-2