eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-09-25 13 3 1281 1289 10.13005/bpj/1997 34569 article R.V.Rohit Vishwanath 1, 2*, 2, 1, R. Vijayashree2, 3 S. Saradha 2 A. Ruckmani 2 A. Sindhana 1 R. Vijayashree 2 T. Sobita Devi 3 Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai-603103, Tamil Nadu, India. Department of Pharmacology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai-603103, Tamil Nadu, India Department of Pathology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai-603103, Tamil Nadu, India Central Animal House, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai-603103, Tamil Nadu, India. Objective: To evaluate the effect of Resveratrol on testicular functions in rapid eye movement (REM) sleep deprived Wistar rats. Method: Eighteen male Wistar albino rats were divided into three groups of 6 rats each. Group1,(Control) had rats with normal sleep/wake cycle. Group 2 and 3 rats were subjected to seven days of REM sleep deprivation. Group 3 in addition received 20 mg/kg/day of Resveratrol. REM sleep deprivation was done using the inverted flower pot technique. Sperm count and motility, testosterone level, and histo pathology of testes was assessed among the three groups. One way ANOVA was used to assess the difference among the groups. p value<0.05 was considered  statistically significant. Results: Sperm count and motility as well as testosterone level were within normal range in group 1. Group 2 had significant reduction in sperm count, motility and testosterone level (p<0.05). Group 3, treated with resveratrol in addition to REM sleep deprivation, showed improved sperm count, motility and testosterone and these levels were equivalent to group 1.The difference between group 2 and group 3 was found to be statistically significant(p <0.05). Histopathological analysis of the testes revealed normal architecture in group 1 and mild spermatogenic disarray with distorted architecture in group 2. However in group 3 no significant change was observed. Conclusion: Resveratrol was found to protect the testis from the damage due to REM sleep deprivation in rats in terms of sperm count, motility, testosterone levels and testicular morphology. https://biomedpharmajournal.org/vol13no3/protective-effect-of-resveratrol-on-rem-sleep-deprivation-induced-changes-in-testicular-functions-in-wistar-rats/ Antioxidants Infertility REM Sleep Deprivation Resveratrol Sperm Testes