eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-09-25 13 3 1495 1504 10.13005/bpj/2023 34966 article We studied the effect of "Nettle Oil" on radiation-induced oxidative damage in the tissues of the heart and lungs. The experiment was performed on 40 Wistar male rats divided into 4 groups. Animals of the first and third groups received intragastric sunflower oil at a dose of 2.5 ml/kg bodyweight for 14 days. Animals of the second and fourth groups - the drug "Nettle Oil" in the same amount and mode. Then, rats of the third and fourth groups, an hour after the last injection of oil, were exposed to gamma radiation (6 Gr). Irradiation toxicity was manifested by an increase in blood serum activity of aspartate, alanine aminotransferase, creatine phosphokinase, lactate dehydrogenase, total cholesterol, triglycerides, low-density cholesterol lipoproteins, atherogenic indices against the background of a decrease in high-density cholesterol lipoproteins. In the tissues of the heart and lungs, the amount of malondialdehyde increased and the activity of superoxide dismutase, catalase, glutathione peroxidase and the level of reduced glutathione and non-protein thiol decreased. The introduction of "Nettle Oil" prior to irradiation provided significant antioxidant protection. Antioxidant enzymes increased along with the levels of reduced glutathione and non-protein thiol, which is associated with a significant decrease in the level of malondialdehyde in the tissues of the heart and lungs. https://biomedpharmajournal.org/vol13no3/effect-of-nettle-oil-on-oxidative-damage-to-the-heart-and-lungs-induced-by-radiation/ Heart Ionizing radiation Lung “Nettle oil” oxidative stress.