eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-09-25 13 3 1513 1521 10.13005/bpj/2025 34997 article Dwi Indria Anggraini 1 Rahadi Rihatmadja 2 Shannaz Nadia Yusharyahya 2 Faculty of Medicine, Universitas Lampung, Indonesia. Department of Dermatology and Venerology, Faculty of Medicine Universitas Indonesia. Inadequate xerosis treatment may result in complications. This study aimed to comparing the efficacy and side effects of moisturizing cream containing 10% urea and 10% lanolin in petrolatum for the treatment of xerosis in elderly. A randomized, double blind clinical trial was conducted in 35 elderly from a nursing home in Jakarta. Evaluation of skin capacitance (SC), specified symptoms sum score (SSRC), and pruritic degree were measured at baseline, week-2 and -4 after the start of therapy. Following a 2-week precondition period, each subject received a random moisturizer for each limb, to be applied twice daily. The percentage of SC increase at week-4 was significantly higher in limb receiving cream containing 10% urea than 10% lanolin/petrolatum (64.54% vs. 58.98%; p=0.036). The percentage of SSRC decrease at week-4 did not differ between groups (100%; p=0.089). Pruritus was equally improved in both groups at week-2, and completely diminished at week-4. Overall, the most frequent side effect was sticky feel, more common, but not statistically significant, in 10% lanolin/petrolatum group. After four-week application moisturizer containing 10% urea gave higher percentage of SC increase than 10% lanolin/petrolatum in the xerotic limbs of the elderly. Sticky feeling was more frequently found in 10% lanolin/petrolatum group, but statistically not significant. https://biomedpharmajournal.org/vol13no3/comparison-between-moisturizing-cream-containing-10-urea-and-10-lanolin-in-petrolatum-in-skin-hydration-improvement-among-elderly/ Elderly 10% lanolin petrolatum 10% urea xerosis.