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<records>

  <record>
    <language>eng</language>
          <publisher>Oriental Scientific Publishing Company</publisher>
        <journalTitle>Biomedical and Pharmacology Journal</journalTitle>
          <issn>0974-6242</issn>
            <publicationDate>2020-09-25</publicationDate>
    
        <volume>13</volume>
        <issue>3</issue>

 
    <startPage>1549</startPage>
    <endPage>1554</endPage>

	 
      <doi>10.13005/bpj/2029</doi>
        <publisherRecordId>35024</publisherRecordId>
    <documentType>article</documentType>
    <title language="eng">A Study of Cutaneous Adverse Drug Reactions; Clinical/Morphological Pattern &#038; Causative Agents Reported in an ADR Monitoring Centre in a Tertiary Care Hospital of North Karnataka</title>

    <authors>
	 


      <author>
       <name>Khot Anant</name>

 
		
	<affiliationId>1</affiliationId>
      </author>
    

	 


      <author>
       <name>S P Chaukimath</name>


		
	<affiliationId>2</affiliationId>

      </author>
    

	 


      <author>
       <name>Janagond Ajit </name>

		
	<affiliationId>3</affiliationId>
      </author>
    

	 


      <author>
       <name>Hugar Leela</name>

		
	<affiliationId>1</affiliationId>
      </author>
    


	


	
    </authors>
    
	    <affiliationsList>
	    
		
		<affiliationName affiliationId="1">Department of Pharmacology, BLDE(DU), Shri. BM Patil Medical College, Vijayapura, India.</affiliationName>
    

		
		<affiliationName affiliationId="2">Department of Psychiatry, BLDE(DU), Shri. BM Patil Medical College and RC, Vijayapura, India.</affiliationName>
    
		
		<affiliationName affiliationId="3">Department of Dermatology, BLDE(DU), Shri. BM Patil Medical College and RC, Vijayapura, India.</affiliationName>
    
		
		
		
	  </affiliationsList>






    <abstract language="eng">Cutaneous adverse drug reactions (CADRs) are common, comprise approximately 2-3% of all the ADRs. Most of them are mild, self-limiting. Severe and potentially life-threatening eruptions occur in approximately 1 in 1000 hospitalised patients. Which carry a high degree of morbidity &amp; mortality. Hence early detection, evaluation and monitoring of ADRs in particular CADRs are essential. As the pattern of CADRs is changing every year with the introduction of new medications &amp; evolving prescription practices. To determine the pattern of various types of CADRs &amp; to identify causative drug implicated in our setup, this study was carried out. A retrospective analysis of the CADRs retrieved from the Pharmacovigilance centre database, reported spontaneously between 25<sup>th</sup> Aug 2015 to 31<sup>st</sup> Oct 2019. The CADRs obtained were categorized according to their morphology &amp; the suspected drugs were grouped according to ATC classification. Causality, severity &amp; preventability assessment was done by using pretested scales. 70 patients had CADRs with male to female ratio of 1:2. Urticaria (37.14%) was the most common CADR &amp; 5.7% of the CADRs were severe.  Anti-infectives for systemic use (48.6%) was predominantly involved in the causation of CADRs. Most of the CADRs belong to a possible category, 75% of them were either recovered or recovering at the time of reporting &amp; only 25% of the CADRs are preventable. Pattern of ACDRs &amp; the drugs causing them are slightly different in our population as compared to other previous studies. Which emphasizes the need for robust ADR monitoring system in our setup.</abstract>

    <fullTextUrl format="html">https://biomedpharmajournal.org/vol13no3/a-study-of-cutaneous-adverse-drug-reactions-clinicalmorphological-pattern-causative-agents-reported-in-an-adr-monitoring-centre-in-a-tertiary-care-hospital-of-north-karnataka/</fullTextUrl>

<keywords language="eng">

      
        <keyword>Cutaneous adverse drug reactions</keyword>
      

      
        <keyword> Pharmacovigilance</keyword>
      

      
        <keyword> Urticaria</keyword>
      
</keywords>
  </record>
</records>