eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-06-25 13 2 805 808 10.13005/bpj/1945 33947 article I Nyoman Gede Budiana 1 Tjokorda Gede Astawa Pemayun 2 I Nyoman Gede Budiana, Sanglah General Hospital, Bali Diponegoro street, 80113 Obstetrics and Gynaecology Department, Udayana University/ Sanglah General Hospital, Bali, Indonesia Gestational trophobalstic neoplasia (GTN) is spectrum of trophoblastic diseases that includes inasive mole, placental site trophoblastic tumor (PSTT), epitheloid trophoblastic tumor (ETT) and choriocarcinoma. The diagnosis of invasive mole is mostly based on clinical findings. In this paper, we report a 40-year-old woman with atypical presentation of invasive mole. She had no complaint, and was incidentally diagnosed after 9 months of amenorrhea during a hospital visit. Clinical diagnosis was difficult due to nonspecific ultrasound findings and low-level β-hCG. Dilatation and curretage failed to obtain sufficient pathologic information, and chemoresistance to methotrexate complicated the treatment. Hysterectomy was finally decided due to progressing uterine enlargement, even after the normalization of serum β-hCG. https://biomedpharmajournal.org/vol13no2/diagnosis-and-treatment-of-an-atypical-invasive-mole-a-case-report/ Invasive Mole Methotrexate Trophoblast