eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-06-25 13 2 613 625 10.13005/bpj/1925 33870 article Nagham Mahmood Aljamali 1 Imad Kareem Alwan Alsabri 2 Professor, Synthetic Chemistry Field, Department of Chemistry, Iraq. Master in Oncology, College of Medicine, Kufa University, Iraq. Cancer tumors cause not few deaths among the total deaths in the world, despite the great progress in the treatment of cancer, so it has become necessary to understand the molecular explanations that contribute to the development and progress of cancer and to search for more effective and less toxic treatments to treat this disease.The work included the innovation and development of the drug trimethoprim by linking it with the innovative compound sulfazane and  creation of several derivatives of sulfazane –trimethoprim for the first time then studying the behavior and impact of innovative compounds on vital activities as anti-cancer tumors by following an innovative  procedures of preparation for sulfazane compounds ,then linking them with several chemical reactions with the drug trimethoprim to develop its effectiveness and efficiency. Several spectral techniques were used to diagnose and demonstrate the formation of innovative derivatives (sulfazane- trimethoprem) thereof (FT.IR - Spectra ,H.NMR – Spectra , HMBC- Spectrum ,Mass Spectra), chemical properties, Flowing  through  TLC ,in addition to  laboratory study of cancerous tumors. The results indicated  to formation of these drug derivatives by appearance of new bands and disappearance of bands in starting compounds., besides to conclusions from our paper that gave good data for inhibition efficiency for these drug derivatives  against cancer cells. https://biomedpharmajournal.org/vol13no2/development-of-trimethoprim-drug-and-innovation-of-sulfazane-trimethoprim-derivatives-as-anticancer-agents/ Azo Coupling Cancer Innovation Invented Compounds New Reaction of  Diazonium Sulfide-Azo Sulfazane Tumor Toxicity Trimethoprim (-S-N=N-)