eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-06-25 13 2 603 612 10.13005/bpj/1924 33906 article Taoufiq Benali 1 Houda Chtibi 1 Abdelhakim Bouyahya 2 Abdelmajid Khabbach 3 Khalil Hammani 1 Laboratory of Natural Resources and Environment, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B.P.: 1223, Taza-Gare. Taza, Morocco Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco Laboratory of Materials, Natural Substances, Environment and Modeling (LMSNEM), Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez B.P.: 1223, Taza-Gare. Taza, Morocco The present study reports the phenol and flavonoid contents of Cistus ladaniferus and Mentha suaveolens from Northern Morocco and the evaluation of their in vitro antioxidant and antimicrobial activities against gram positive, gram negative bacteria, and yeast. The results showed that the highest phenol and flavonoid content found in the aqueous extract of Cistus ladaniferus. However, the methanol extract of Mentha suaveolens contains the high phenol and flavonoid contents.  A significant anti-DPPH activity was obtained with aqueous extract of Mentha suaveolens and Cistus ladaniferus with IC₅₀ values of 8.78 ± 0.02μg/mL and 2.93± 0.02μg/mL, respectively. An important anticandidal effect of MSEO as observed against Candida albicans. The most sensitive bacteria to all extracts were B. subtilis, P. mirabils and S. aureus.  Our findings indicate that the natural compounds of Cistus ladaniferus and Mentha suaveolens with an antimicrobial activity could be a good target for the antioxidants and antimicrobial industry. However, further investigations regarding the isolation of phenolic bioactive compounds and the evaluation of their antioxidant and antimicrobial properties are required. https://biomedpharmajournal.org/vol13no2/detection-of-antioxidant-and-antimicrobial-activities-in-phenol-components-and-essential-oils-of-cistus-ladaniferus-and-mentha-suaveolens-extracts/ Antioxidant Activity Antimicrobial Activity Cistus Ladaniferus Mentha Suaveolens Phenol Content