eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-03-28 13 1 281 290 10.13005/bpj/1887 31102 article Marat Iztleuov 1 Abdiraman Kaliev 1 Aigul Turganbaeva 2 Dariga Yesmukhanova 1 Ainur Akhmetova 1 Yerbolat Iztleuov 3 Department of Natural Sciences, Faculty of Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan Department of Pathological Anatomy and Forensic Medicine, Faculty of Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan Department of Radiation diagnostics, Faculty of Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan Course of dermatovenerology, Faculty of Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan The purpose of this research is to study the effect of sodium tetraborate on chromium-induced oxidative damage in lung tissue. The experiment was conducted on 60 «Wistar» male rats (170-190g.) which were divided into 6 groups. The first group is control; the second, third, fourth groups received potassium dichromate (K₂Cr₂O₇) with drinking water at a dose of 700 mg/l for 21 days; the fifth and sixth groups of animals received orally a solution of sodium tetraborate (Na₂B₄O₇) at a dose of 22.5 mg/kg and 225 mg/kg of body weight per day for 31 days. Animals of the third and fourth groups received orally Na₂B₄O₇ at doses of 22.5 mg/kg and 225 mg/kg per day, respectively, for ten days before receiving K₂Cr₂O₇, then for 21 days, co-administration of potassium dichromate. Introduction of K₂Cr₂O₇ caused a change in the endopulmonary cytogram, significantly reduced the nonspecific mechanism of respiratory protection from external influences, increased the content of malonic dialdehyde (p<0.05) and same as previous. Co-administration of Na₂B₄O₇ (22.5 mg/kg) with K₂Cr₂O₇ improves the mucociliary index (anti-inflammatory effect - the effect of debridement), inhibits oxidative damage (oxidative stress) in the lung tissue (antioxidant effect) in comparison with the data of animals exposed to K₂Cr₂O₇. The combined use of Na₂B₄O₇ in a high dose with K₂Cr₂O₇ did not show the expected positive effect. Oxidative stress in the lung tissue induced by K₂Cr₂O₇ leads to changes in the endopulmonary cytogram, disturbances in the mucociliary index, the balance of prooxidants/antioxidants in the lung tissue, to an increase in the peroxidation of lipids and inhibition of the antioxidant system. Sodium tetraborate, depending on the dose (at a low dose of 22.5 mg/kg body weight), can protect lung tissue from chromium-induced oxidative damage. However, with the introduction of sodium tetraborate in a high dose with chromium, the expected positive effect is not observed. https://biomedpharmajournal.org/vol13no1/the-effect-of-sodium-tetraborate-on-chromium-induced-oxidative-damages-in-rats-lung-tissue/ Chromium-Induced Oxidative Damage Potassium Dichromate Respiratory Protection Sodium Tetraborate