eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-03-28 13 1 175 184 10.13005/bpj/1874 30779 article Astrid Feinisa Khairani 1 Umar Islami 2 Mas Rizky Anggun Syamsunarno 3 Uci Ary Lantika 4 Division of Cell Biology, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia Graduate School of Biomedical Sciences Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia Division of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia Department of Histology and Medical Biology, Faculty of Medicine, Universitas Islam Bandung, Bandung, West Java, Indonesia Dyslipidemia has high prevalence worldwide. Unhealthy diet such as high calories and high fat contribute to dyslipidemia. Purple sweet potato yogurt is a synbiotic product containing combination of probiotic fermentation and natural ingredient (prebiotic). Probiotics give beneficial effect to intestinal function. Purple sweet potato serves as prebiotic, also contains anthocyanin as antioxidant. This experimental study aimed to identify the effect of purple sweet potato yogurt consumption towards lactic acid bacteria colony in the intestine, lipid profile (total cholesterol, triglyceride, LDL), body weight, visceral fats, and liver weight of male mice model (Balb-c) with high fat diet. Total of 30 male mice were divided into six groups with different treatment on its diet. Lipid profiles were investigated using enzymatic colorimetric assay. Statistical data was analyzed using one-way ANOVA and post hoc tukey multiple comparison test. Result shown that in the group with administration of 0.3 mL of purple sweet potato yogurt had significantly increase the growth of lactic acid bacteria in the intestine (p<0.0001). The same group also shown favorable outcome in total cholesterol, triglyceride, LDL level, visceral fat and liver weight. Purple sweet potato yogurt has potential protective effect in lipid metabolism under high fat diet condition. Thus, further study is needed to explore more detail on its mechanism. https://biomedpharmajournal.org/vol13no1/synbiotic-purple-sweet-potato-yogurt-ameliorate-lipid-metabolism-in-high-fat-diet-mice-model/ Anthocyanin Dyslipidemia High Fat Diet Lipid Profile Lactic Acid Bacteria Synbiotic