eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-03-28 13 1 423 427 10.13005/bpj/1902 31161 article Muhammad Yulis Hamidy 1 Huriatul Masdar 2 Darmawi3 2 Department of Pharmacology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia Department of Histology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia To evaluate mangrove (Rhizophora sp) fruit extract effect on foam cell formation at the initiation stage of atherosclerosis. The study was conducted on 18 rats divided into 3 groups (n=6). Group 1 was given a standard diet, Group 2 was given a high cholesterol diet, and Group 3 was given a high cholesterol diet and mangrove fruit extract 500 mg/kg. The mangrove fruit extract effect on foam cell formation was assessed by histopathologic examination using hematoxylin eosin staining. The results showed that the number of foam cells was increased significantly in high cholesterol diet-fed rats compared to standard diet-fed rats (21.17 vs. 11.75). Mangrove fruit extract reduced this number remarkably (21.17 vs. 12.67). In conclusion, mangrove fruit extract inhibits the formation of foam cells at the initiation stage of atherosclerosis. https://biomedpharmajournal.org/vol13no1/effect-of-mangrove-rhizophora-sp-fruit-extract-on-foam-cell-formation-at-the-initiation-stage-of-atherosclerosis/ Atherosclerosis Foam Cell Mangrove Fruit Extract