eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2020-03-28 13 1 489 496 10.13005/bpj/1910 30831 article Ismiarto YD 1 Budi MNS 2 Mahyudin 3 Head of the Study Program of Department of Orthopaedics and Traumatology Faculty of Medicine Padjadjaran University dr. Hasan Sadikin General Hospital, Indonesia Orthopaedic oncologist consultant of Orthopaedics and Traumatology Faculty of Medicine Padjadjaran University dr. Hasan Sadikin General Hospital, Indonesia Resident Department of Orthopaedics and Traumatology Faculty of Medicine Padjadjaran University dr. Hasan Sadikin General Hospital, Indonesi A femoral fracture is a trauma with a high mortality rate. Long bone fracture cases frequently related to missing bone segments, that can disrupt the bone healing. The process of defect fracture healing requires internal and external mechanical stimulation, external stimulation can be stimulated using low-intensity pulsed ultrasounds. Clinical studies have shown a significant positive effect from LIPUS in the treatment of non-union fractures and accelerated fracture repair compared to fractures treated with a placebo of 38%. The purpose of this study was to determine the effectiveness of LIPUS on the healing of defect femoral fractures in rabbit post-ORIF plate and screw-based on radiological measurements. This study is a comparative, unpaired laboratory experimental study with two treatment groups and one control group. The treatment group consists of group I that was given LIPUS 30 mW/cm2 for 10 minutes per day and Group II 30 mW/cm2 for 20 minutes per day, Group III without LIPUS treatment as the control group. Radiological assessment was performed to assess callus formation based on the Tiedemann score. After that data is collected, data editing, coding, entry were carried out and analyzed statistically. There were significant differences between treatment group and control group towards callus diameter formation, between-group I, II and control with mean of Tiedemann in each group 97.76; 169.83; 76.88; with p-value < 0.05. LIPUS can enhance fracture healing in rabbit femur defects based on radiography measurement. https://biomedpharmajournal.org/vol13no1/efectivity-of-low-intensity-pulsed-ultrasound-on-rabbit-femur-post-orif-plate-and-screw/ Fracture Femur Healing Mechanical LIPUS Radiological