eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-12-28 12 4 2143 2149 10.13005/bpj/1849 29901 article Fenty Alia 1 Mas Rizky A.A Syamsunarno 2,3 Vanessa Ayu Sumirat 4,5 Mohammad Ghozali 2 Nur Atik 2 Characteristics of obesity as dysfunction of adipose tissue and chronic low-grade inflammation can have impacts to haematological parameters. The Moringa oleifera leaves have been used empirically to treat metabolic and blood-related diseases. However, it is still unknown whether Moringa oleifera leaves can influence haematological parameters in high fat diet. The study aimed to investigate the hematological parameter of high-fat diet mice in parallel with Moringa oleifera leaves ethanol extract (MOLE). Forty male DDY mice in 5 weeks of age were randomly divided into five groups as follows: The SD group was fed with a standard diet, the HFD group was fed with high fat diet, the HFD+S group was fed with high-fat diet and simvastatin (0,8 mg/20gBW/day). The HFD+MOLE1 and the HFD+MOLE2 groups were fed with high-fat diet and MOLE in a dose of 5,6 mg/20gBW/day and 11,2 mg/20gBW/day, respectively. The experiment was performed for 7 weeks. At the end of the experiment, blood was drawn for haematology analysis of blood parameters. We found that sub-chronic high fat diet might alter the haematological parameters. Two different doses of MOLE might have potencies to prevent the worsening caused by those alterations, by increased of haemoglobin [12,9(10,4-15,3) vs 13,9(12,9-18,2) and 14(10,2-14,8), p>0,05)], slight decreased of WBC [(3,59±1,974) vs (3,433±1,747) and (3,42±1,014), p>0,05]. Additionally, the MOLE might have an effect to decreasing the granulocyte percentage [18,5(9,2-43,6) vs 11,5(7,6-18,2) and 8,05(3,2-25,1), p>0,05], and slight decreased of MPV [4,2(2,6-6,7) vs 3,6(3,2-4,1) and 3,55(2,6-6,8), p>0,05]. In summary, the study showed that MOLE might have potencies to prevent the worsening of hematological parameters in the sub-chronic high fat diet. https://biomedpharmajournal.org/vol12no4/the-haematological-profiles-of-high-fat-diet-mice-model-with-moringa-oleifera-leaves-ethanol-extract-treatment/ High fat diet Haematological parameter  Moringa oleifera leaves ethanol extract.