eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-12-28 12 04 1887 1891 10.13005/bpj/1819 29485 article Moushira Zakia 1 Taghreed Shalabi 2 Tamer Hussein 3 Mohamed Hammam 4 Eman Youness 5 Hala T. El-Bassyouni 6 Biological Anthropology Department, Medical Research Division, National Research Centre,Egypt Prenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Division, National Research Centre, Egypt Reproductive Health Research Department, Medical Research Division, National Research Centre, Egypt Obstetrics and Gynecology-Cairo University Medical Biochemistry Department, Medical Research Division, National Research Centre, Egypt Clinical Genetics Department,Human Genetics and Genome Research Division, National Research Centre, Giza, Egypt Oxidative stress, inflammation, and vascular endothelial proliferation and obesity are risk factors associated with preeclampsia (PE). Thepresent study aimed to investigate the levels of malondialdehyde (MDA) as a putative circulatory marker of oxidative stress, neutrophil Elastase (NE) as inflammatory marker andvascular endothelial growth factor (VEGF) as marker for vascular permeability-enhancing activities inobese women withpreeclampsia PE and compare withnormal pregnancy women. The study was carried out on 50 pregnant obese women with PE and 50 normal pregnant women.  The preeclampsia women were characterized with high blood pressure 160/110 mmHg and proteinuria. The gestational age ranged from ≥32 weeks to <37 weeks. Pre pregnancyweightwas recorded. Body mass index (BMI) was calculatedat delivery.SerumMDA, NEand VEGF were estimatedby ELISA. Significant higher levels of serum MAD,NE and VEGF were observed in obese PE patients as compared to normal controls. Our results suggested thatobesity;oxidative stress, NEandVEGFbiomarkers are risk factors for PE,emphasizing their role as feasible candidate risk markersfor cases withhigh blood pressure in early pregnancy. https://biomedpharmajournal.org/vol12no4/oxidative-stress-neutrophil-elastaseand-vascular-endothelial-growth-factor-in-obese-pregnant-women-with-preeclampsia/ Malonaldehyde Neutrophil Elastase  Preeclampsia VEGF