eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-12-28 12 04 2027 2036 10.13005/bpj/1835 29548 article Arpita Rai 1 Musarrat Siddiqui 2 Shama Parveen 3 Saba Parveen 2 Abdur Rasheed 2 Sher Ali 3 Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia. New Delhi. 110025 Faculty of Dentistry, Jamia Millia Islamia, New Delhi.110025 Centre for Interdisciplinary Research in Basic Sciences ,Jamia Millia Islamia. New Delhi. 11002 Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is believed to be the most potent etiological factor. The role of reactive oxygen species (ROS), epithelial-mesenchymal transition (EMT) and various cytokines and growth factors has been established in recent studies. The components of areca nut particularly, arecoline, flavonoids and copper have been found to affect fibroblasts, endothelial and epithelial cells through various biological pathways which are either down-regulated or up-regulated during different stages of the disease. However, the underlying molecular pathogenesis of OSMF is still partially understood. https://biomedpharmajournal.org/vol12no4/molecular-pathogenesis-of-oral-submucous-fibrosis-a-critical-appraisal/ oral submucous fibrosis OSF OSMF reactive oxygen species TGF EMT