eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-09-25 12 3 1329 1338 10.13005/bpj/1761 28400 article Munesh Kumar 1 Rajesh Thakur 1 Sandeep Kumar 2 Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar. Department of Veterinary Physiology and Biochemistry, LUVAS, Hisar. Syzygium cumini is well known for its medicinal values in the indigenous Indian system of medicine. This study was designed to evaluate the protective effect of methanolic (SCM), ethanolic (SCE) and aqueous (SCA) extracts of Syzygium cumini seeds on arsenic-induced blood cell genotoxicity and hepatotoxicity in Wistar albino rats. Rats were divided into five groups: (1) control, (2) arsenic, (3) SCM, (4) SCE and (5) SCA. After completion of 60 days treatment period, comet assays were performed on isolated blood lymphocytes and serum marker assays indicative of hepatic toxicity were carried out. Arsenic exposed rats expressed significantly higher DNA damage in their lymphocytes than the unexposed rats. Increased activities of serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), and decreased levels of total proteins were observed in arsenic exposed rats. Simultaneous administration of Syzygium cumini seed extracts significantly decreased the arsenic-induced DNA damage and hepatotoxicity. The amelioration of arsenic toxicity was more pronounced with methanolic extract compared to ethanolic and aqueous extracts of Syzygium cumini seeds. https://biomedpharmajournal.org/vol12no3/comparative-efficacy-of-syzygium-cumini-seed-extracts-in-alleviating-arsenic-induced-hepatotoxicity-and-blood-cell-genotoxicity-in-wistar-albino-rats/ Antioxidants  Arsenic  Genotoxicity  Reactive Oxygen Species  Syzygium Cumini