eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-06-25 12 2 571 578 10.13005/bpj/1676 27562 article Inès Christelle Chadon Alphonsine Assemian 1 Abdelhakim Bouyahya 1 Nadia Dakka 1 Youssef Bakri 1 Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat 10 000, Morocco Garcinia mangostana L. is medicinal plant. Its fruit, the mangosteen contains many bioactive xanthones. This study investigates the potential of organic leaf extracts of G. mangostana grown in Ivory Coast. We tested two organic leaf extracts: G. mangostana aqueous ethanolic leaf extract (ethanol: water, 80:20 v/v) (GMLE) and dichloromethane leaf extract (GMLD). We measured total phenolic and total Flavonoids. We analysed the in vitro anti-inflammatory, anti-radical and anti-proliferative activities of leaf extracts. Ethanol leaf extract showed a considerable amount of phenolic content (328.78±34.32 mg GAE/g) and moderate flavonoids content (43.60±1.48 mg QE/g), Dichloromethane extract had low values of phenolic (70.31±4.55 mg GAE/g) and flavonoids (8.49±0.69 mg QE/g). However, GMLD extract gave a significant anti-inflammatory activity (IC₅₀=152.79±3.34 µg/mL), comparable to the standard drug diclofenac sodium (IC₅₀=142.30±1.22 µg/mL), contrary to GMLE extract (IC₅₀=652.33±12.23 µg/mL). The radical scavenging assay showed a very significant ability of ethanol leaf extract to reduce the DPPH radical (IC₅₀=33.40±0.67 µg/mL) compared to references molecules such as Trolox (IC₅₀=43.72±0.31 µg/mL) and acid ascorbic (IC₅₀=27.20±0.17 µg/mL), dichloromethane extract results showed lowest activity (IC₅₀ = 580.00±23.03 µg/mL). All the organic leaf extracts of G. mangostana had moderate anti-proliferative activity on L20B, RD and VS cell lines studied with IC₅₀ values ranging from 110.89 ±4.82 µg/mL to 860.60±25.78 µg/mL). Our results prove the high potential of the G. mangostana leave extracts as anti-inflammatory and anti-oxidative stress drugs. However, further studies are to determine and validate all the medicinal properties of G. mangostana leaves extracts. https://biomedpharmajournal.org/vol12no2/garcinia-mangostana-leaf-extracts-from-ivory-coast-possess-remarkable-antioxidant-anti-inflammatory-and-cytotoxicological-properties/ Anti-Cancer Anti-Inflammatory Anti-Radical Garcinia Mangostana Leaf Extracts