eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-06-25 12 2 609 618 10.13005/bpj/1681 27613 article Marat Iztleuov 1 Gulnara Temirova 2 Muslima Bashbayeva 3 Zhanat Komyekbay 2 Yerbolat Iztleuov 4 Zhanibyek Madikhan 1 Department of Natural Sciences, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Department of Gystology, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Continuing Professional Development Center, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Department of Radiation diagnostics, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. The cardioprotective effects of sodium tetraborate in chromium intoxication, correction of lipid profile and oxidative stress have been investigated. The experiment has been performed on 36 Wistar male rats, divided into 6 groups. I - control; II, III, and IV groups received potassium bichromate (K₂Cr₂O₇) 700 mg/l with drinking water; rats of the III and IV groups received additionally orally a solution of sodium tetraborate (Na₂B₇O₇) in doses of 22.5 mg/kg and 225 mg/kg per day, respectively. Animals of the V and VI groups received orally only Na₂B₇O₇ solution at the rate respectively 22.5 and 225 mg/kg weight per day. The study duration was 21 days. The introduction of K₂Cr₂O₇ increases content of malondialdehyde and carbonial protein in cardiac tissue, activates the antioxidant system of the heart, expands the levels of biomarkers of cardiotoxicity and increases the atherogenic index. The introduction of Na₂B₇O₇ (22.5 mg/kg) reduces the toxic effect of K₂Cr₂O₇ (cardioprotective effect). The use of Na₂B₄O₇ (225 mg/kg) does not give a positive effect. In the group receiving only Na₂B₄O₇ (22.5 mg/kg), inhibition of lipid oxidation and protein is observed, decrease of toxicity of biomarkers and low density lipoprotein-cholesterol (LDL-C), i.e. antioxidant effect. On the contrary Na₂B₄O₇ (225 mg/kg) shows the prooxidant property. https://biomedpharmajournal.org/vol12no2/effect-of-sodium-tetraborate-on-oxidative-damages-in-heart-tissue-in-chromium-intoxication/ Heart Lipid Profile Oxidative Stress Potassium Bichromate Protective Effect Rats Sodium Tetraborate