eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-03-25 12 1 141 147 10.13005/bpj/1622 25543 article I. Gusti Ngurah Made Suwarba 1 Soetjiningsih 1 I. Made Bakta 2 I. Made Jawi 3 I. Dewa Made Sukrama 3 I. Wayan Putu Sutirta Yasa 4 Department of Child Health, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia. Department of Internal Medicine, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia. Department of Pharmacology, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia. Department of Clinical Pathology, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali-Indonesia. Department of NeuroPediatric, Faculty of Medicine, University of Indonesia-RSCM Hospital, Jakarta-Indonesia. The water extract of purple sweet potato contains of anthocyanin, a sub-class of flavonoid that has powerful antioxidant, antiinflammatory, and anticonvulsant effect. The aim of this study was to determine the effectiveness of supplementation of water extract of purple sweet potato towards recovery (remission) of drug resistant focal epilepsy (DRFE) in children with standard conventional  antiepileptic medicine. It was found that the supplementation of purple sweet potato extract had a pure effect in improving all of the dependent variables, including decreased of the serum level of 8-OHdG by 1.611 pg/mL (p<0.001); decreased the serum level of IL-6 by 3.320 pg/mL (p<0.001); increased the total SOD serum level by 0.208 IU/mL (p=0.003); improved the EEG image (p=0.004); and decreased the seizure frequency at the end of the sixth week by 3.972 times (p<0.001), compared to the control. There is a significant effect on the use of supplementation of purple sweet potato extract in decreasing the serum level of 8-OHdG, decreasing the serum level of IL-6, increasing the total SOD serum level, improving the EEG image, decreasing the seizure frequency at the end of the sixth week, which at the end reducing the frequency of drugs resistant of focal epilepsy in children. https://biomedpharmajournal.org/vol12no1/supplementation-of-water-extract-of-purple-sweet-potato-ipomoeo-batatas-l-in-improving-the-eeg-image-decreasing-the-seizure-frequency-and-reducing-the-frequency-of-drugs-resistant-of-focal-epilepsy/ Children DRFE Epilepsy Purple Sweet Potato Seizure