eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-03-25 12 1 117 129 10.13005/bpj/1620 26693 article Elsharabasy F. S. 1 Metwally N. S. 2 Mahmoud A. H. 2 Soliman M. S. 2 Youness E. R. 3 Farrag A. H. 4 Department of Chemistry, Prince Sattam Bin Abdul-Aziz University, Saudi Arabia and Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Egypt. Department of Chemistry Therapeutic, Pharmaceutical Industries Research Division, National Research Center, Dokki, Egypt. Department of Biochemistry Medical, Medical Research division, National Research Center, Dokki, Egypt. Department of Pathology, National Research Center, Dokki, Egypt. Department of Biology, Prince Sattam Bin Abdulaziz University, Saudi Arabia and Department of Botany, Faculty of Science, Cairo University, Egypt. The objective of this study is to investigate the chemical constituents of Suaeda monoica and Suaeda pruinosa and evaluate their effects on rat liver intoxicated by over dose of paracetamol. Qualitative analysis of (80%) methanol in water fraction revealed the presence of alkaloids, terpenoids, steroids, tannins, quinones, saponins, flavonoids and phenols from two mangrove species of S. monoica and S. pruinosa was carried out. The compounds were identified from the 80% methanol-H₂O fraction as Rutin, quercetin, Syringic acid, Coffeic acid, Catechin, Coumaric acid, Vanillin, Gallic acid, Cinnamic acid. Amino acids analysis for the methanolic extract from the aerial parts of Suaeda monoica and Suaeda pruinosa showed the presence of thirteen amino acids and absence of valine, Isoleucine, Phenylalanine. Fatty acid analysis of lipids showed high percentage of long chain fatty acids.TLC of the lipoidal matter for each plant showed the presence β-amyrin, β-sitosterol and stigmasterol. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly improved liver and kidney function with prophylactic or therapeutic treatments. Histopathological and histochemical studies showed parallel effects with the biochemical measured parameters. https://biomedpharmajournal.org/vol12no1/phytoconstituents-and-hepatoprotective-effect-of-suaeda-monoica-forssk-and-suaeda-pruinosa-lange/ Hepatoprotection Paracetamol  Secondary Metabolites  Suaeda Sp.