eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-03-25 12 1 3 6 10.13005/bpj/1607 26323 article M. Sankari 1 S. Swarna Meenakshi 1 Department of Periodontics, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai, India. Melatonin is a substance that is secreted by multiple organs in Humans. In addition to playing a role in the regulation of the circadian cycle, it is also known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is an easy target for many conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research on melatonin as a therapeutic agent has suggested that it is effective in treating the aforementioned pathologic conditions effectively. Furthermore, melatonin tends to favour bone regeneration by behaving as an osteoconductive scaffold. The aim of this review is to summarize the uses and potential of melatonin in management of periodontal diseases. https://biomedpharmajournal.org/vol12no1/melatonin-in-periodontal-diseases-a-review/ Anti Oxidant Bone Formation Inflammation Melatonin Oral Cavity Periodontitis