eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-03-25 12 1 357 362 10.13005/bpj/1648 26359 article In-Vitro Studies on Antitumour and Antimicrobial Activities of Methanolic Kernel Extract of Mangifera Indica L. Cultivar Banganapalli N. Venkata Raju 1 Karuganti Sukumar 2 G. Babul Reddy 3 P. K. Pankaj 4 Muralitharan G. 2 Shanti Annapareddy 1 Vignan's Foundation for Science, Technology and Research, Vadlamudi, Guntur, 522213, India. Department of Microbiology, Bharathidasan University, Tiruchirapalli, Tamilnadu, 620024, India. R and D Center, SOM Phytopharma (India) Limited, Hyderabad,502325, India. ICAR-Central Research Institute for Dryland Agriculture, Hyderabad, 500059, India. Mangifera indica L. belongs to the family Anacardiaceae and is considered as “King of all Fruits”. Mango kernels are discarded as waste after the industrial processing and it has several proven medicinal benefits. Attempts were made to study its antitumour and antimicrobial activities. In the current research work, 15 local cultivars of Mangifera indica L. were collected with a motto to screen the best cultivar having high total phenolic content, flavonoid content, antitumour property and antimicrobial activity. Banganapalli cultivar of mango showed high total phenolic content and total flavonoid content i.e. 63.5±1.1 mg GAE/g and 16.7±0.5 mg quercetin/g followed by Royal special cultivar (TPC-58.7±0.6 mg GAE/g TFC-16.2±0.6 mg quercetin/g). Mangifera indica L. cultivar Banganapalli which showed highest total phenolic content and total flavonoid content was screened for its antitumour and antimicrobial properties. Antitumour property was tested by using potato disc assay which recorded 40.12% tumour inhibition percentage. Antimicrobial activity was assessed by agar diffusion method by taking 3 test microorganisms viz. Bacillus subtilis subsp. subtilis DSM 10, Staphylococcus aureus MTCC 737 and Escherichia coli MTCC 46. The measured area of inhibition is around Staphylococcus aureus MTCC 737 in 8.5±0.3 mm followed by E.coli MTCC 46 (8.2±0.3 mm) and Bacillus subtilis sub subtilis (6.6±0.5 mm). The present study showed that the mango kernels which were generally discarded as waste has antitumour and antibacterial properties and further studies need to be carried out. https://biomedpharmajournal.org/vol12no1/in-vitro-studies-on-antitumour-and-antimicrobial-activities-of-methanolic-kernel-extract-of-mangifera-indica-l-cultivar-banganapalli/ Antimicrobial Activity  Antitumour Activity  Banganapalli  Kernels  Mangifera Indica L.