eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2019-03-25 12 1 171 173 10.13005/bpj/1625 26624 article Made Lely Rahayu 1 I. Made Bakta 2 Wayan Suardana 1 Nyoman Mantik Astawa 3 I. G. K. Arijana 4 I. Ketut Tunas 5 Department of Otorhinolaryngology- Head and Neck surgery Faculty of Medicine Udayana University/Sanglah General Hospital Denpasar, Bali, Indonesia. Departement of Internal Medicine Faculty of Medicine Udayana University/Sanglah General Hospital Denpasar, Bali, Indonesia. Pathobiology Laboratory of Faculty of Veterinary Medicine Udayana University, Bali, Indonesia. Department of Histology Faculty of Medicine Udayana University, Bali, Indonesia. Department of Public Health, Faculty of Health, Science and Technology, Dhyana Pura University, Bali, Indonesia. Hoya carnosa leaves or tebel-tebel leaves are known by the Balinese people in the countryside to treat middle ear infections in the medical language, otitis media or “curek” in the Balinese language. The study is true experimental randomized posttest-only control group design to evaluate the impact of ethanol extract sample as antibacterial. As antibacterial, the extract has an impact on the thickness of stroma middle ear epithelium with otitis media due to Pseudomonas Aeruginosa. The result showed average mean thickness stroma in the treatment group lower than controls. https://biomedpharmajournal.org/vol12no1/ethanol-extraction-of-hoya-carnosa-leaves-improved-stroma-of-middle-ear-epithelium-infected-by-pseudomonas-aeruginosa/ Ethanol Extract Hoya Carnosa Middle Ear  Pseudomonas Aeruginosa  Stroma