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<records>

  <record>
    <language>eng</language>
          <publisher>Oriental Scientific Publishing Company</publisher>
        <journalTitle>Biomedical and Pharmacology Journal</journalTitle>
          <issn>0974-6242</issn>
            <publicationDate>2019-03-25</publicationDate>
    
        <volume>12</volume>
        <issue>1</issue>

 
    <startPage>227</startPage>
    <endPage>232</endPage>

	 
      <doi>10.13005/bpj/1631</doi>
        <publisherRecordId>26571</publisherRecordId>
    <documentType>article</documentType>
    <title language="eng">Correlation between Hasford Score with Early Molecular Response in Patients with Chronic Myeloid Leukemia in Chronic Phase Treated with Imatinib</title>

    <authors>
	 


      <author>
       <name>I. Dewa Made Widi Hersana </name>

 
		
	<affiliationId>1</affiliationId>
      </author>
    

	 


      <author>
       <name>Ugroseno Yudho Bintoro </name>


		
	<affiliationId>1</affiliationId>

      </author>
    

	 


      <author>
       <name>Ami  Ashariati</name>

		
	<affiliationId>1</affiliationId>
      </author>
    

	 


      <author>
       <name>Made Putra Sedana</name>

		
	<affiliationId>1</affiliationId>
      </author>
    


	


	
    </authors>
    
	    <affiliationsList>
	    
		
		<affiliationName affiliationId="1">Hematology and Medical Oncology Division, Department of Internal Medicine,  Universitas Airlangga-Dr Soetomo Teaching Hospital, Surabaya, Indonesia.</affiliationName>
    

		
		
		
		
		
	  </affiliationsList>






    <abstract language="eng">The aim of the study is to to determine correlation Hasford score and early molecular response in chronic phase BCR-ABL-Positive CML patients treated with imatinib. This is an longitudinal observational study in newly diagnosed patients of CML chronic phase BCR-ABL-Positive treated imatinib from Januari 2017 to September 2017. Patients were stratified according to Hasford score at diagnosis. Q-PCR(Quantitative RT-PCR) were used to monitor BCR-ABL transcription levels after 3 months of imatinib treatment.  Correlation between Hasford score with early molecular response were analyzed using Koefisien Kontingensi’s correlation test. Results: Thirty five patients were enrolled in this study consist of 13 male and 22 female. After 3 months of imatinib treatment, EMR were 5 patients (83.3%), 11 patients (61.1%) and 2 patients (18.2%) in low, intermediate, and high risk group patients, respectively. Koefisien kontigensi test showed that there was significant correlation between Hasford score and EMR (p=0.018; r=0.431). The Hasford score correlated to early molecular response in chronic phase BCR-ABL-positive CML patients received imatinib.</abstract>

    <fullTextUrl format="html">https://biomedpharmajournal.org/vol12no1/correlation-between-hasford-score-with-early-molecular-response-in-patients-with-chronic-myeloid-leukemia-in-chronic-phase-treated-with-imatinib/</fullTextUrl>

<keywords language="eng">

      
        <keyword>Chronic Phase BCR-ABL-Positive CML</keyword>
      

      
        <keyword> Early Molecular Response</keyword>
      

      
        <keyword> Hasford Score</keyword>
      

      
        <keyword> Imatinib</keyword>
      
</keywords>
  </record>
</records>