eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-12-25 11 4 1801 1806 10.13005/bpj/1552 24743 article Ziyad S. Haidar 1,2 BioMAT’X, Facultad de Odontología, Universidad de los Andes, Santiago, Chile. CIIB, Facultad de Medicina, Universidad de los Andes, Santiago, Chile. In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the χ² minimization method, is employed concluding that the Korsmeyer-Peppas model provides the best-fit in all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed. https://biomedpharmajournal.org/vol11no4/mathematical-modeling-for-pharmacokinetic-predictions-from-controlled-drug-release-nanosystems-a-comparative-parametric-study/ Drug dissolution  Least squares method  Mathematical modelling Model comparison  Release kinetics  Statistical analysis