eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-12-25 11 4 1781 1787 10.13005/bpj/1549 24660 article Cibele da Cruz Prates 1 Liege Helena Freitas Fernandes 1 João Baptista da Costa Agra de Melo 2 Catarina Ribeiro Barros de Alencar 1 Alessandro Leite Cavalcanti 1 School of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil. Department of Mechanical Engineering, Federal University of Campina Grande, Campina Grande, PB, Brazil. To analyze the effect of intra-oral application of CPP-ACP and CPP-ACPF pastes on the surface hardness of initial dental erosion lesions.Bovine enamel specimens were randomly assigned into 6 volunteers in 3 treatment groups: GI: CPP-ACP paste, GII: CPP-ACPF paste and GIII (Control): Placebo paste without CPP-ACP and without fluoride. Enamel specimens were selected by surface hardness (SHi), in vitro eroded by immersion in hydrochloric acid for 30 seconds (SHdes) and randomized between treatment groups and volunteers, who used the palatal intraoral device for 2 hours, applied the treatment on the specimens and used the palatal intraoral device for an additional 3 hours in 3 crossed phases, interspersed with a 7-day washout period. Subsequently, the surface hardness (SHre) was measured to estimate the re-hardening potential of the softened enamel promoted by treatments. Data were analyzed using the t-test and one-way ANOVA, adopting 5% significance level. Mean final and post-erosion hardness values were statistically significant for pastes tested (p<0.05), which presented re-hardening effect of the softened enamel, but with no difference between them and placebo (p>0.05). CPP-ACP and CPP-ACPF pastes did not demonstrate higher efficacy in re-hardening the eroded enamel compared to placebo paste. https://biomedpharmajournal.org/vol11no4/effect-of-cpp-acp-and-cpp-acpf-pastes-on-the-surface-hardness-of-initial-dental-erosion-lesions-an-in-situ-study/ Caseins  Tooth Erosion  Toothpastes