eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-09-21 11 3 1397 1401 10.13005/bpj/1503 21665 article Iskandar Muda 1 Nur Atik 2 Biomedical Sciences Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. Psidium guajava Linn. is a cultivated and herbal medicines from tropical and subtropical areas that extensively consume around the world as a food and folk medicine. Recent study showed that extract of P. guajava increased the number platelets in thrombocytopenia mice model. The purpose of this research is to know the profile of liver function after high dose treatment of P. guajava extract in mice. The test of acute toxicity was based on up and down procedure of OECD 425. The 7 female mice was divided into 3 groups. The first group was taken as a control with distillated water treatment, the second group as a test group with 2000 mg/kg b.w of P. guajava. extract and the third group as a test group with 5000 mg/kg b.w of P. guajava. extract treatment. Blood of all mice was collected to analyze biochemical test, including ALT, AST and Total Bilirubin. We found that the observation of biochemical tests by statistical approach is no differences in levels of ALT, AST and Total Bilirubin from control and both treatment groups (p≥ 0.05). The extract of P. guajava is safe for liver function. https://biomedpharmajournal.org/vol11no3/profile-of-liver-function-in-mice-after-high-dose-of-psidium-guajava-linn-extract-treatment/ ALT AST guajava Linn Liver P. Total Bilirubin