eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-09-21 11 3 1423 1428 10.13005/bpj/1506 22158 article Parithimar kalaignan 1 Jaya shree Mohan 1 Department of Prosthodontics, Vinayaka missions Sankarachariyar dental college, Salem. Cancers of the orofacial region can be devastating in their impact on physical structure and function of the affected individual, leading to potentially severe compromises in quality of life. A total of Twenty (20) mandibular resected patients were selected for this study. All the patients’ were rehabilitated with mandibular resection prosthesis. Novel scale known as Maxillofacial Prosthesis Performance Scale (MFPPS) was developed for mandibulectomy patients to assess the oral health related quality of life. This scale has been tested for validity and reliability.  The OHRQol was measured using the oral health impact profile (OHIP-Edent-19), Obturator functioning scale (OFS-15) and Maxillofacial Prosthesis Performance Scale (MFPPS-10) with standardized questionnaire after 2 weeks & 3months of prosthesis function for twenty (20) mandibular resected patients.   For OHIP –Edent scale; when comparing 2 weeks, all subscale scores shown significant progress on oral health impact profile-Edent scale after 3 months of prosthesis function. For OFS scale; when observing the score of 2 weeks and 3 months, there was dramatic improvement of (75%) in miscellaneous factors which include Problems in dryness of mouth, engagement in social events and obturator positioning.  For MFPPS; all rehabilitated patients’ were observed two weeks later, negative impacts have been eliminated and positive impacts increased on oral health. The patient was reviewed again 3months later and confirming an even higher level of overall satisfaction with the Mandibular Resection Prosthesis. The maxillofacial prosthesis had a strong positive impact on quality of life .Hence mandibular resection prosthesis enhance the oral health related quality of life. https://biomedpharmajournal.org/vol11no3/oral-health-related-quality-of-life-with-mandibular-resection-prosthesis/ Mandibular Resection Prosthesis Maxillofacial Prosthesis Performance Scale Obturator Functioning Scale Oral Health Impact Profile–Edent