eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-06-25 11 2 1083 1090 10.13005/bpj/1469 21128 article Wassef Girgiss Nicola 1 Mina Wassef Girgiss 1 Aly Mohamed Ezz El-Arab 2 Dawoud Fakhry Habib 3 Mohamed Elsayed Elnemr 4 Nadia Mohamed Ahmed 3 Internal Medicine, Endocrinology and metabolism-Department of Internal Medicine, Medical Division, National Research Centre (NRC), Cairo, Egypt. Nutrition-Department of Nutrition and Food Science, National Research Centre (NRC), Cairo, Egypt. Biochemistry-Medical Biochemistry Department, Medical Division, National Research Centre (NRC), Cairo, Egypt. Internal Medicine, Department of Internal Medicine, 6th October University-Egypt. Systemic inflammation describes certain metabolic alterations which are mediated by inflammatory cytokines. Theses occur essentially as a defensive body response towards offending agents such as surplus nutrient staffs. Our aim is to find out the role of inulin as a protective agent against metabolic inflammation. Twenty eight type 2 diabetic females were subjected to the estimation of their serum high sensitivity C-reactive protein, lipopolysaccharides, tumor necrosis factor alpha, adiponectin and HOMA-IR test before and after three weeks of inulin ingestion. There was a significant drop in the level of serum high sensitivity C-reactive protein, lipopolysaccharides, tumor necrosis factor alpha, HOMA-IR and a non-significant rise in serum adiponectin after inulin ingestion. In summary inulin can act as a useful protective agent in systemic inflammation. https://biomedpharmajournal.org/vol11no2/role-of-inulin-in-the-protection-and-management-of-metabolic-inflammation-in-humans-by/ Adiponectin   Tumor Necrosis Factor Alpha  HOMA-IR   High Sensitivity C-reactive Protein Inulin Lipopolysaccharides Metabolic Inflammation