eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-06-25 11 2 1015 1021 10.13005/bpj/1460 21046 article Jaya Kusuma AAN 1 Suwiyoga K 1 Mantik AN 2 Sukrama DM 3 Maternal-Fetal Medicine Division, Obstetrics and Gynaecology Department, Faculty of Medicine, Udayana University/Sanglah General Hospital, Denpasar, Bali, Indonesia. Pathobiology Laboratory of Faculty of Veterinary Medicine Udayana University, Denpasar Bali, Indonesia. Clinical Microbiology Department,Faculty Of Medicine,Udayana University/Sanglah General Hospital,Denpasar, Bali Indonesia. Pre-eclampsia (PE) still a problem of Maternal Fetal Medicine service related to high incidence, maternal and neonatal morbidity and mortality. Pre-eclampsia is caused by pregnancy, however, the mechanism has not been established so it is still a disease of theories. This relates to differences in treatment, resulting in different ways of prevention and output of PE itself. Recently, the role of 2-ME was suspected to be very important in the mechanism of the PE. Meanwhile, the placenta acts as a source regulatory protein production, so that the material of this study was taken from placental tissue. The study objective was to prove the low 2-ME expression in the placenta as a risk factors for PE and a case control study has been conducted in the department of obstetrics and gynecology Sanglah Hospital with 62 samples in 2015. The case group consisted of 31 mother with PE and control groups consisted of 31 non-PE mother. The study material is a placental tissue. Examination of 2-ME expression with ELISA techniques in Pathobiology Laboratory Faculty of Veterinary Medicine Udayana University. Data were analyzed with chi square test and discriminant using SPSS. The statistical test results are presented in tabular form and narrative. In this study, it was found that low expression of 2-ME increased the risk of PE 5 times higher (OR = 5.23; CI95% = 1.75 to 15.55; p = 0.002 https://biomedpharmajournal.org/vol11no2/low-expression-of-2-methoxyestradiol-2-me-on-placenta-tissue-as-a-risk-factor-of-pre-eclampsia/ 2-Methoxyestradiol  Pre-eclampsia