eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-03-25 11 1 411 416 10.13005/bpj/1388 19063 article Silvia W Lestari 1,4 Manggiasih D. Larasati 2 Indra G. Mansur 1,4 Ria Margiana 3,4 Department of Medical Biology, Faculty of Medicine Universitas Indonesia. Master Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia. Department of Anatomy, Faculty of Medicine Universitas Indonesia. The Indonesian Reproductive Medicine Research and Training Center, Ina-Repromed. Current highlight on the etiology of male infertility is a disorder in sperm motility  which is caused by ion homeostasis imbalance involving the ubiquitous multifunctional transmembrane protein, Na⁺K⁺-ATPase and Ca²⁺-ATPase enzymes. The emphasis of this review is evaluating the use of sperm’s Na⁺K⁺-ATPase and Ca²⁺ATPase activity as predictive parameters of sperm motility disorder. To this purpose, a computerized search of PubMed database was performed and obtained data were reviewed in this paper. The retrieved studies were laboratory experiments involving human and mice sperm as the subjects. Na⁺ K⁺-ATPase and Ca²⁺-ATPase play an essential role in sperm motility by controlling ion homeostasis. Na⁺ K⁺-ATPase maintains the intracellular pH by transporting 3 Na⁺ out and 2 K⁺ into the cell, whereas Ca²⁺-ATPase extrudes Ca²⁺ from the cell. The impairment of these enzymes and its isoforms, Na⁺ K⁺-ATPase α4 and PMCA4 expression were proved to decrease sperm motility. https://biomedpharmajournal.org/vol11no1/sperm-na-k-atpase-and-ca2-atpase-activities-a-potential-predictive-parameter-of-sperm-motility-disorder-in-infertile-men/ Ca²⁺ATPase Male Infertility Na⁺ K⁺-ATPase  Sperm Motility