eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-03-25 11 1 227 236 10.13005/bpj/1367 18844 article Yerbolat Iztleuov 1 Talgar Abilov 2 Ganiya Zhanabayeva 3 Irina Ismailova 4 Marat Iztleuov 2 Department of Radiation diagnostics, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Department of Natural sciences, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Department of General dentist, Faculty of Stomatology, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Department of General medical practice, Faculty of Medicine, West–Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Hexavalent chromium presents a particular threat due to its high toxicity. In this study showed the neuroprotective effect of sodium tetraborate in chromic intoxication. The experiment was performed on Wistar rats divided into 4 groups: 1 group - control; 2 group - single intraperitoneal injection of K₂Сr₂O₇ in a dose of 0,5LD₅₀, in the 3 and 4 groups with drinking water received Na₂B₄O₇. Animals of the 3 group - 4 mg/kg of body weight, in 4 group - 72 mg/kg of body weight daily for 10 days, the last administration of Na₂B₄O₇ was combined with a single intraperitoneal injection of K₂Сr₂O₇ at a dose of 14 mg/kg (0,5LD₅₀). Na₂B₄O₇ in a dose of 4 mg/kg leads to a decrease in the level of MDA by 33%, an increase in the activity of catalase by 69%, superoxide dismutase by 21%, GR by 49%. Na₂B₄O₇ at a dose of 72 mg/kg increases the MDA content by 31% in comparison with the data of rats of chromic intoxication. K₂Сr₂O₇ reduces the GSH level by 42%, the non-protein thiol by 36%. Na₂B₄O₇ at a dose of 4 mg/kg increased the GSH level by 53%, the non-protein thiol by 35%, and at a dose of 72 mg/kg reduced the GSH content by 23% (ρ<0.05), the non-protein thiol by 20% (ρ<0.05) in comparison with the data of rats exposed to K₂Сr₂O₇. https://biomedpharmajournal.org/vol11no1/protective-effect-of-sodium-tetraborate-on-chromium-induced-brain-damage-in-rats/ Antioxidant System Bichromate Potassium Brain Damage Lipid Peroxidation Sodium Tetraborate