eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-03-25 11 1 525 530 10.13005/bpj/1403 18715 article A. Nizar Ahmed 1 Ramakrishnan 2 Dj. Victor 3 Faculty of Dental sciences Sri Ramachandran university Porur Chennai. Adhiparashakthi Dental College and hospital Melmaruvathur. Srm Dental college and hospital Ramapuram Chennai. To identify the presence of periodontal pathogens Tannerella Forsythia (T.f) and Treponema Denticola (T.d) in Down syndrome (DS) and systemically healthy subjects with periodontitis. 60 age matched subjects were categorized into three groups; Group I: 20 DS subjects with periodontitis, Group II: 20 Systemically healthy subjects with periodontitis, Group III: 20 Systemically healthy subjects without periodontitis. Plaque samples from all the three groups were collected and analyzed to evaluate the presence of T.f and T.d using Polymerase Chain Reaction. The indices that were used include Oral Hygiene Index Simplified, Community Periodontal Index For Treatment Needs and Plaque index. This study showed a statistically significant detection in the levels of T.f and T.d in DS. There was a statistically significant presence of T.d and T.f in DS subjects compared to systemically healthy periodontitis and controls. https://biomedpharmajournal.org/vol11no1/identification-of-tannerella-forsythia-and-treponema-denticola-in-down-syndrome-subjects-and-healthy-subjects-with-periodontal-disease-a-pcr-study/ Chronic Periodontitis Down Syndrome  Oral Hygiene Subgingivalmicro Flora Taneralla Forsythia Treponema Denticola