eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2018-03-25 11 1 149 157 10.13005/bpj/1356 19155 article Gomaa Mostafa-Hedeab 1,2 Alaa Abdelhamed Mohamed 3,4 Gamal Thabet 5 Dina Sabry 6 Randa Fayez Salam 7 Manal Ewaiss Hassen 3,4 Department of Pharmacology, Faculty of medicine, Aljouf University, KSA. Department of Pharmacology, Faculty of medicine, Beni Suef University, Egypt. Department Biochemistry unit- pathology, Faculty of medicine, Aljouf University, KSA. Department of Biochemistry, Faculty of medicine, Beni Suef University, Egypt. Department of Clinical pathology, National Cancer Institute, Cairo University, Egypt. Department of Biochemistry, and Molecular Biology, Faculty of medicine Cairo University, Egypt. Objective: to study the effect of MATE 1, MATE 2 and OCT1 genetic variants on metformin action in recently diagnosed Egyptian Type-2 diabetic patients. Patients & Methods: One hundred type-2 DM patients and forty healthy control were included in the study. All patients were recently diagnosed receiving no treatment before participation in the study. Three single nucleotide polymorphisms (SNPs) were Genotyped using real time PCR, Sequence Detection System: MATE1 (rs2252281), OCT1 coding variants (rs12208357) (SLC22A1) and MATE2 (rs12943590). Results: there is a significant differences between control and patients regarding MATE2 (p<0.05), OCT1 (P<0.005) distribution; in which GG (54%), CC (62%) is the most prevalent among studied patients respectively.  MATE1 SNP; Patients with CC alleles and TT allele had better HBA1C (8.577±.2924), (8.7±.25) compared to CT allele patients (9.584±.3023) (P= .04) (P=.019) respectively. OCT1 SNP; CG allele patients showed better RBS (251±9.565) compared to CC allele (294.42±8.476) (p=0.004). Logistic regression test showed that RBS (p=.00001), ALT (p=.0001) and TLC (p=.025) are independent factors affecting blood glucose. Conclusion: MATE1 and OCT1 SNPs may have a potential role in metformin efficacy. https://biomedpharmajournal.org/vol11no1/effect-of-mate-1-mate-2-and-oct1-single-nucleotide-polymorphisms-on-metformin-action-in-recently-diagnosed-egyptian-type-2-diabetic-patients/ Diabetes Egyptian MATE 1 MATE 2 and OCT1 SNPs