eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-12-21 10 4 1773 1777 10.13005/bpj/1291 17704 article I. Made Sukadana 1 Sri Rahayu Santi 2 I. G. K. Arijana 2 Department of Chemistry-Faculty of Science and Maths Udayana University Bali Indonesia. Histology Laboratory-Faculty of MedicineUdayana University Bali Indonesia. This study aimed to evidence the potent antiatherosclerosis of n-buthanol extract Inocarpus fagiferus Fosb stem bark through biomarker  SOD-2 and SOD-3expression aortic endhotelial cell  of wistar rats hypercholesterolemia within 4 months of observation. The n-buthanol concentrate extract was applied to wistar rats for 4 months use to the posttest only control group design. Twenty-five wistar rats were randomized into 5 groups such as P₀ (negative control), P₁ (positive control, hypercholesterolemia), P₂ (hypercholesterolemia + n-buthanol extract in the dose of 50 mg/kg bw), P₃ (hypercholesterolemia + n-buthanol extract in the dose of 100 mg/kg bw), and P₄ (hypercholesterolemia + n-buthanol extract in the dose of 150 mg/kg bw). The study showed that n-buthanol extract stem bark of Inocarpus fagiferus Fosb in the dose of 50 mg/kg bw was able to increase the expression of SOD-2 aortic endhotelial cells in wistar rats hypercholesterolemia significantly (p<0.05), but it was not significantly (p>0.05)  for SOD-3 expression. https://biomedpharmajournal.org/vol10no4/the-intake-of-inocarpus-fagiferus-fosb-stem-bark-n-buthanol-extract-caused-the-increase-expression-of-sod-2-and-sod-3-aortic-endhotelial-cells-of-hypercholesterolemia-rats/ Antiatherosclerosis Hypercholesterolemia Inocarpus Fagiferus Fosb SOD-2 SOD-3