eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-12-21 10 4 1709 1714 10.13005/bpj/1283 17443 article Shahnaz Majeed 1 Faculty of Pharmacy and Health sciences Universiti Kuala Lumpur Royal College of Medicine Perak, 30450 Ipoh, Perak, Malaysia. The present study focusses on the extracellular synthesis of silver nanoparticles (AgNPs) from Alternaria alternate isolated from soil at the Unikl RCMP tasek campus. The colour of the fungal filtrate has been changed into dark brown upon the addition of 1mM silver nitrate (AgNO3) suggest the nanoparticle formation. These nanoparticles were characterized by UV-vis spectrophotometric showed the absorption peak at 370nm. High resolution electron transmission electron (HRTEM) was used to determine the structure, size and shape of nanoparticles which were spherical, polydispersed and size was15 to 30 nm. These nanoparticles were evaluated for antibacterial activity against Escherichia coli and Staphylococcus aureus showed excellent antibacterial activity and also enhanced the antibacterial property of gatifloxacin and also it showed good antifungal activity against Aspergillus niger and candida albicans subsequently and enhances the antifungal activity of fluconazole. https://biomedpharmajournal.org/vol10no4/biosynthesis-and-characterization-of-nanosilver-from-alternata-alternaria-and-it-antifungal-and-antibacterial-activity-in-combination-with-fluconazole-and-gatifloxacin/ Alternate Alternaria  Antibacterial Activity Antifungal Activity HRTEM