eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-12-21 10 4 2113 2120 10.13005/bpj/1335 18239 article Venkata Naveen Kumar P, 1 Elango P, 1 Asmathulla S. 2 S. kavimani 3 Department of Pharmacology Sri Ramachandra Medical College and Research Institute, Porur Chennai. Department of biochemistry Sri ManakulaVinayagar Medical College and Hospital Pondicherry. Department of Pharmacology Mother Theresa Post Graduate Institute and Research Institute of Health Science Pondicherry. Oxidative stress is an important risk factor for various diseases. Dietary consumption of carotenoids like lycopene attenuates the oxidative stress in human beings, also widely distributed in fruits, vegetables like tomato, watermelon, and guava. Antioxidant, and a free radical scavenger property by its unique structure, it is believed to be primarily responsible for various biological effects, supported by sound scientific evidence.The Present systematic review outlines the currently available data on lycopene sources, structure, its absorption, and its beneficial role in chronic diseases. It shows protective against alzheimer disease by improving cognitive functions by protecting oxidative damage of mitochondrial enzymes and preventing apoptosis. Systemic inflammation exacerbates more co-morbidities in chronic obstructive pulmonary diseases lycopene attenuates this condition by its antioxidant property. It regulates osteoporosis by decreasing bone turnover and osteoclast activity with an increase in osteoclast activity. Lycopene reduces neuropathic pain by increasing the expression of connexin (CX43) expression in the dorsal horn of spinal cord which maintains neuropathic pain. https://biomedpharmajournal.org/vol10no4/a-systematic-review-on-lycopene-and-its-beneficial-effects/ Alzheimer Diseases Cardiovascular Chronic Obstructive Pulmonary Diseases Diseases Lycopene