eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-09-25 10 3 1071 1072 10.13005/bpj/1204 15800 article C. Deepak 1 Arvind Ramanathan 2 1Department of Orthodonics, Bharath University Chennai, India. Sree Balaji Dental College and Hospital Bharath University Chennai, India. MSX1 gene is among the Homeo box genes . The Master genes that control the downstream genes and are involved in the patterning of the face . MSX 1 deficient  mice have shown to have cleft palate and missing teeth . Several studies have been done , which have shown a  relationship between non syndromic cleft lip and palate and the MSX1 gene .  As Human studies on MSX1 and non syndromic clp are rare , this systematic review was done to see if there were sufficient literature to support the same . Three search data bases were taken , , Pubmed , Science direct and Cochrane were searched using the key words .  Pub med showed 5  , Science direct 79 and Cochrane 1 articles. Further  using the inclusion criteria , 5 articles were selected . Human studies involved populations from across the world . https://biomedpharmajournal.org/vol10no3/role-of-msx1-gene-in-orofacial-clefting-a-systematic-review/ Non Syndromic cleft lip and palate MSX1 gene systematic review