eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-09-25 10 3 1097 1100 10.13005/bpj/1208 16113 article Deepak Chandrasekharan 1 Arvind Ramanathan 2 Department of Orthodontics, Bharath University Chennai, India. Sree Balaji Dental College and Hospital Bharath University Chennai, India. The search for the genetic etiology of non syndromic clefting has been pursued for some time now . Amongst the probable genes that could be involved in NSCLP , the IRF6 gene has shown to be linked .With  a lot of studies that have implicated the IRF6 gene to NSCLP ,there was a need to have a systematic review of the literature available and to find the association of IRF6 gene to NSCLP . The review was designed to search the common scientific search bases, Pubmeb , Cochrane and Science direct were chosen. Pub med direct displayed  27 , Science direct 50 and Cochrane 0 articles .Further using the specific inclusion criterias comprising   a, a direct association of the IRF6 gene mutation to  non syndromic orofacial clefting b, human subjects with Non Syndromic Orofacial Clefting , 3 articles were selected . The selected studies found a strong link between the IRF6 gene and  Non syndromic Orofacial clefting , reported from different populations around the world. https://biomedpharmajournal.org/vol10no3/role-of-irf6-gene-in-orofacial-clefting-a-systematic-review/ IRF6 gene  Non syndromic clefting Literature review