eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-09-25 10 3 1207 1212 10.13005/bpj/1222 16099 article Maysaa Jalal Majeed 1 Medicine College -Baghdad University, Baghdad-Iraq. Betatrophin, is a new bioactive peptide of 198 amino acids, also known as ANGPTL8, is coded by the Gm6484 gene in mice liver and fat, betatrophinwhich recently found to promote a dramatic proliferation of pancreatic βcells in a S961 induced insulin resistance mouse model it is expressed in the, white and brown adipose tissue of mice. In humans, betatrophin is expressed in the liver. Evaluation of betatrophin as a treatment used for diabetes as an alternate treatment to insulin was studies in mice with type 1 diabetes and comparing the result with control group this study conclude that betatrophin lower blood sugar which lower necessity of depending the patient on insulin. https://biomedpharmajournal.org/vol10no3/impress-of-betatrophin-in-the-treatment-of-mice-with-diabetes-type-1/ Betatrophin bioactive peptide insulin immunosorbent