eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-09-25 10 3 1475 1479 10.13005/bpj/1255 16484 article Essam Fadel Al-Jumaily 1 Nagham Qasim Abd 1 Biotechnology Department Genetic Engineering and Biotechnology Institute for postgraduate studies, University of Baghdad, Iraq. Sixty isolates of Pseudomonas aeruginosa were collected from different hospitals of Baghdad. Detection of mexB gene in the isolates was done by using PCR technique and the gene was found in all of the isolates.The susceptibility of the isolates was tested against Carbenicillin, Levofloxacin and Erythromycin by using disc diffusion method.Results showed that 80% of the total isolates was resistant to Carbenicillin while 6% and 32% of the total isolates was resistant to Levofloxacin and Carbenicillin respectively.Three isolates that were resistant to the three antibiotics were chosen to be the base for detecting the gene expression level of mexB before and after the addition of Quinoline-2-one Derivatives. https://biomedpharmajournal.org/vol10no3/effect-of-quinoline-2-one-derivatives-on-the-gene-expression-of-mexb-of-pseudomonas-aeruginosa/ Carbenicillin Erythromycin Levofloxacin mex Bgene Pseudomonas aeruginosa    Quinoline-2-one Derivatives