eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2017-09-25 10 3 1427 1432 10.13005/bpj/1249 16595 article Made Lely Rahayu 1 Komang Andi Dwi Saputra 1 Eka Putra Setiawan 1 Departement of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine Udayana University, Sanglah General Hospital, Denpasar, Indonesia. The objective of the study was to screening and compare anti bacterial activity of Hoya carnosa leaves extract, Chloramphenicol 1% and Ciprofloxacin against bacteria Staphylococcus and Pseudomonas aeruginosa that cause benign type Chronic Suppurative Otitis Media (CSOM). Hoya carnosa leaves extract, Chloramphenicol 1 % and Ciprofloxacin were subjected to screening and compare their antibacterial activity against two strains of bacteria species, Staphylococcus aureus, Pseudomonas aeruginosa that taken from culture ears secretions of patients active benign type of CSOM. The study using standard protocol Disc Diffusion Method (DDM). Antibacterial activity were assessed by the presence or absence of inhibition zones and minimal inhibitor capacity (MIC) values.  Ciprofloxacin had the most powerful bacterial activity in Disc Diffusion Methods (DDM) with mean rank 13, then Chloramphenicol  with mean rank 8 and the weakest is the Hoya carnosa leaves extract with mean rank 3.There significant differences among antibacterial activity of Hoya carnosa leaves extract, Chloramphenicol 1% and topical Ciprofloxacin against two strains of bacteria species, Staphylococcus aureus and Pseudomonas aeruginosa.   https://biomedpharmajournal.org/vol10no3/antibacterial-activity-extract-hoya-carnosa-leaves-chloramphenicol-1-and-ciprofloxacin-against-staphylococcus-aureus-and-pseudomonas-aeruginosa-that-caused-benign-type-chronic-suppurative-otitis-med/ Hoya carnosa chronic suppurative otitis media